City lost the away leg 4-0 in Spain and are second in Group C, one point in front of Borussia Monchengladbach.
Sergio Aguero is expected to start for City on Tuesday, and right-back Pablo Zabaleta could be available.
"We dropped two points against Celtic, so we have to recover those points," said the former Barcelona manager. "It's not a final for them, it is a final for us."
Aguero started the game at the Nou Camp on the bench but, following two goals in a win over West Brom in the Premier League on Saturday, is expected to start.
"We have to be focused for 90 minutes, knowing they are going to provoke mistakes because of the quality they have," added Guardiola.
"But we had a few chances [in the first game] and have to keep going in that sense and try to finish better than we did in Barcelona.
"We will try. I have never entered a match thinking we can't win but we have to play almost perfectly."
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